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Compare biological models, docking engines, and computational workflows side-by-side. Filter by access model, compute footprint, and category to reach an actionable decision table in under a minute.
| Attribute | Research Imaging & Microscopy RELION-5MRC Laboratory of Molecular Biology (Scheres Lab)Open Source⚡ A100/H100 | ＋ Add tool | ||
|---|---|---|---|---|
| Category | Research Imaging & Microscopy | Research Imaging & Structural Analysis | Research Imaging & Structural Analysis | — |
| Subcategory | Cryo-EM 3D Reconstruction | Conventional or Statistical Baselines | Cell Segmentation | — |
| Company | MRC Laboratory of Molecular Biology (Scheres Lab) | Research / method authors | Van Valen Lab | — |
| Access mode | Open Source | Confirm distribution and exact release | Research code or publication | — |
| Licence conditions | GPL-3.0 | NOT_INDEPENDENTLY_AUDITED | Check code and model weights separately | — |
| Compute requirements | Multi-GPU workstation or cluster (NVIDIA GPUs with >= 16GB VRAM, fast NVMe scratch storage) | Version and data dependent | Check selected checkpoint and runtime; no GPU catalog recommendation | — |
| Biological application | Atomic-resolution macromolecular structure determination (proteins, viruses, ribosomes) | Not recorded | Not recorded | — |
| Research workflow | Cryo-EM movie micrographs -> motion correction -> particle picking -> 3D density map | Not recorded | Not recorded | — |
| Evidence level | Primary software used for thousands of atomic structures deposited in the Protein Data Bank (PDB) | OFFICIAL_DOCUMENTATION | Peer-reviewed primary method | — |
| Commercial eligibility | Open source release | NOT_INDEPENDENTLY_AUDITED | Unknown, requires audit | — |
| Price | Free Open Source | Verify access and licence | Check selected model licence | — |
| Availability ⓘ | Available on GitHub and CCP-EM | Method paper or official documentation | Public research method/code | — |
| Features | Empirical Bayesian algorithms for 2D class averaging and 3D reconstruction, High-resolution CTF refinement and per-particle beam-induced motion correction, GPU acceleration for processing massive multi-terabyte movie datasets, Integrated model-building and validation tools for macromolecular complexes | CellProfiler scientific method, Microscopy images and configured classical image-analysis modules, Segmented objects and quantitative image features | Automated cell instance segmentation using detector and Segment Anything models for supported microscopy., Individual cell instance masks | — |
| Entry type | Scientific Software | Classical/statistical scientific method | Research AI model / method | — |
| AI role | Bayesian Image Reconstruction | NON_AI_CLASSICAL | Published biomedical AI method | — |
| Input data | Not recorded | Microscopy images and configured classical image-analysis modules | Microscopy images; chosen checkpoint and pixel size | — |
| Output data | Not recorded | Segmented objects and quantitative image features | Individual cell instance masks | — |
| Validation | Not recorded | Published method scope; no independent BioAtlas execution or benchmark | Requires independent dataset-specific evaluation | — |
| Type | Cryo-EM image processing suite | Not recorded | Not recorded | — |
| Intended use | Not recorded | Not recorded | Not recorded | — |
| Compatibility | Not recorded | Not recorded | Not recorded | — |
| Manufacturer | MRC Laboratory of Molecular Biology | Not recorded | Not recorded | — |
| Integration evidence | https://relion.readthedocs.io | Not recorded | Not recorded | — |
| Laboratory handoff | Generates 3D density maps for atomic model building and drug binding validation | Not recorded | Not recorded | — |