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| Attribute | Research Imaging & Microscopy RELION-5MRC Laboratory of Molecular Biology (Scheres Lab)Open Source⚡ A100/H100 | ＋ Add tool |
|---|---|---|
| Category | Research Imaging & Microscopy | — |
| Subcategory | Cryo-EM 3D Reconstruction | — |
| Company | MRC Laboratory of Molecular Biology (Scheres Lab) | — |
| Access mode | Open Source | — |
| Licence conditions | GPL-3.0 | — |
| Compute requirements | Multi-GPU workstation or cluster (NVIDIA GPUs with >= 16GB VRAM, fast NVMe scratch storage) | — |
| Biological application | Atomic-resolution macromolecular structure determination (proteins, viruses, ribosomes) | — |
| Research workflow | Cryo-EM movie micrographs -> motion correction -> particle picking -> 3D density map | — |
| Evidence level | Primary software used for thousands of atomic structures deposited in the Protein Data Bank (PDB) | — |
| Commercial eligibility | Open source release | — |
| Price | Free Open Source | — |
| Availability ⓘ | Available on GitHub and CCP-EM | — |
| Features | Empirical Bayesian algorithms for 2D class averaging and 3D reconstruction, High-resolution CTF refinement and per-particle beam-induced motion correction, GPU acceleration for processing massive multi-terabyte movie datasets, Integrated model-building and validation tools for macromolecular complexes | — |
| Entry type | Scientific Software | — |
| AI role | Bayesian Image Reconstruction | — |
| Input data | Not recorded | — |
| Output data | Not recorded | — |
| Validation | Not recorded | — |
| Type | Cryo-EM image processing suite | — |
| Intended use | Not recorded | — |
| Compatibility | Not recorded | — |
| Manufacturer | MRC Laboratory of Molecular Biology | — |
| Integration evidence | https://relion.readthedocs.io | — |
| Laboratory handoff | Generates 3D density maps for atomic model building and drug binding validation | — |