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Biological Foundation Model of the Year (2026)

Recognizing the model that has most profoundly advanced zero-shot prediction and macromolecular generation across sequence, structure, and dynamics.


AlphaFold 3

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By Google DeepMind & Isomorphic Labs

Diffusion-based all-atom prediction for protein-DNA-RNA-ligand complexes.

1,420 votes33.3%

ESM-3 (98B)

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By EvolutionaryScale

Simultaneous multimodal generation across sequence, structure, and functional active sites.

1,285 votes30.1%

Chai-1

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By Chai Discovery

Multimodal biomolecular structure prediction with open weights and commercial friendliness.

890 votes20.9%

Evo DNA Foundation Model

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By Arc Institute & Stanford

7-billion parameter long-context genomic transformer predicting whole operons.

670 votes15.7%
💊

Breakthrough Small Molecule AI of the Year

The highest-performing machine learning architectures for molecular docking, ultra-large library screening, and ADMET profiling.


DiffDock / DiffDock-L

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By MIT CSAIL

Equivariant diffusion over rigid body and torsional degrees of freedom.

1,120 votes41.9%

Boltz-1

By MIT & Valence Labs

Open-source all-atom biomolecular model rivaling commercial proprietary systems.

940 votes35.2%

Uni-Mol

By DP Technology

3D molecular pre-training architecture for quantum chemistry and binding affinity.

610 votes22.8%
🌟

Best Open Source Biology Tool

Championing transparent, reproducible, and community-owned software in life sciences.


RFdiffusion

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By Baker Lab / IPD

Generative protein backbone scaffolding by reversing the noise process.

1,650 votes42.9%

ProteinMPNN

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By Baker Lab

Fast and robust deep learning sequence design for fixed protein backbones.

1,380 votes35.8%

OpenFold

By OpenFold Consortium / Columbia

Trainable, PyTorch-native recreation of AlphaFold2 with complete training code.

820 votes21.3%
🤖

Lab Automation & Robotics Innovation

Transforming wet-lab execution through AI-guided robotic orchestration and cloud laboratories.


Opentrons Flex AI

By Opentrons

Liquid handling with onboard computer vision, LLM protocol generation, and API control.

980 votes43.0%

Emerald Cloud Lab (ECL)

By Emerald Therapeutics

Remote-controlled automated laboratory executing hundreds of standard analytical assays.

760 votes33.3%

Automata LINQ

By Automata Tech

Modular robotic arms connecting multi-vendor diagnostic and screening instruments.

540 votes23.7%

🏛️ BioAtlas Hall of Fame (Past Winners)

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2025: AlphaFold 3

Google DeepMind · Foundation Model of the Year
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2024: RFdiffusion

Baker Lab · Open Source Tool of the Year
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2023: ESM-2

Meta FAIR · Protein Language Model of the Year