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ESM-3 is a 98-billion parameter generative language model that simultaneously reasons over protein sequence, 3D structure, and biological function, capable of generating novel fluorescent proteins from scratch.
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ESM-3 is a 98-billion parameter generative language model that simultaneously reasons over protein sequence, 3D structure, and biological function, capable of generating novel fluorescent proteins from scratch.
Information checked against an official source; not a hands-on test. Source · Last reviewed: 20/09/2026, 11:09:40 UTC
Use this citation format when referencing ESM-3 in scientific publications and benchmark papers.
@software{esm_3_2026,
title = {{ESM-3}},
author = {{EvolutionaryScale}},
year = {2026},
url = {https://www.evolutionaryscale.ai},
note = {Indexed on aibioatlas - AI for Biology and Drug Discovery}
}Live scientific citations queried from Europe PMC and PubMed for ESM-3.
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ESM-3 Official Photographic Architecture · Credit: EvolutionaryScale · Open original ↗
Research and editorial use Source & attribution ↗ License ↗
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