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ESM-3

By EvolutionaryScale →

Multimodal language model reasoning over sequence, structure, and function

ESM-3 is a 98-billion parameter generative language model that simultaneously reasons over protein sequence, 3D structure, and biological function, capable of generating novel fluorescent proteins from scratch.

Simultaneous multimodal generation across sequence, coordinates, and secondary structurePromptable with structural motifs, active site geometries, or sequence fragmentsDemonstrated de novo generation of fluorescent proteins with 500M years of divergent evolutionAvailable in 1.4B open weights, 7B, and 98B parameter frontier configurations
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Overview

ESM-3 is a 98-billion parameter generative language model that simultaneously reasons over protein sequence, 3D structure, and biological function, capable of generating novel fluorescent proteins from scratch.

Information checked against an official source; not a hands-on test. Source · Last reviewed: 20/09/2026, 11:09:40

Key Features

  • Simultaneous multimodal generation across sequence, coordinates, and secondary structure
  • Promptable with structural motifs, active site geometries, or sequence fragments
  • Demonstrated de novo generation of fluorescent proteins with 500M years of divergent evolution
  • Available in 1.4B open weights, 7B, and 98B parameter frontier configurations
Interactive 3D Structure

ESM-3 Predicted Complex

Streams real 3D atomic coordinates from RCSB Protein Data Bank
⇄ Drag to rotate · Scroll to zoom
pLDDT / B-Factor:
>90 Very high 70-90 Confident 50-70 Low <50 Very low

Academic Context & Research Evidence

Biological & Workflow Fit

Biological Application
De novo protein generation, motif scaffolding, and functional sequence design
Research Workflow
Structure & function generation from biological prompts
Compute & Hardware
1x A100 GPU (1.4B open model) to multi-node H100 clusters (98B model)
Licensing & Academic Use
EvolutionaryScale Open Model License (1.4B) / Commercial Cloud API
Documented Evidence
View validation publication / source ↗

Cite this Tool

Use this citation format when referencing ESM-3 in scientific publications and benchmark papers.

@software{esm_3_2026,
  title = {{ESM-3}},
  author = {{EvolutionaryScale}},
  year = {2026},
  url = {https://www.evolutionaryscale.ai},
  note = {Indexed on aibioatlas - AI for Biology and Drug Discovery}
}

Peer-Reviewed Literature & Preprints

Live scientific citations streamed from Europe PMC and PubMed for ESM-3.

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Technical / Product Information

Missing values mean the catalog has no recorded information. They do not mean a feature is absent.

Entry typeAI Model
Access modeOpen weights & Cloud API
AI roleMultimodal Generative AI
Input dataNot recorded
Output dataNot recorded
Licence conditionsEvolutionaryScale Open Model License (1.4B) / Commercial Cloud API
Commercial eligibilityCommercial API & enterprise licenses available; non-commercial for open weights
Compute requirements1x A100 GPU (1.4B open model) to multi-node H100 clusters (98B model)
ValidationNot recorded
TypeGenerative protein language & structure model
Intended useNot recorded
CompatibilityNot recorded
ManufacturerEvolutionaryScale
Biological applicationDe novo protein generation, motif scaffolding, and functional sequence design
Research workflowStructure & function generation from biological prompts
Evidence levelPeer-reviewed research and experimental wet-lab validation (Science 2024)
Integration evidencehttps://www.evolutionaryscale.ai/blog/esm-3-release
Laboratory handoffOutput FASTA sequences can be sent directly to gene synthesis vendors (Twist, IDT)
AvailabilityGlobally available via AWS Bedrock and EvolutionaryScale API
Price / accessFree open weights (1.4B) / Paid enterprise API

Research fit & compatibility

No software–hardware integration has been verified for this entry yet. Explore documented research workflows.

Gallery & resources

No licensed product photograph recorded for ESM-3 yet. Visit the official resource below for manufacturer imagery.

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FAQ

Where is this product available?

Globally available via AWS Bedrock and EvolutionaryScale API

How is pricing handled?

Prices reflect the source at its last check. Confirm current pricing and regional availability on the official site.

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Peer Reviews & Community Ratings

Feedback from researchers and computational biologists evaluating ESM-3.

5.0
★★★★★Based on 0 researcher evaluations
Biological Accuracy
4.8/5
Ease of Installation
4.3/5
Documentation & Code
4.6/5