RFdiffusion All-Atom (RFdiffusionAA)

Biological & Workflow Fit

Biological Application

Enzyme active site design, small molecule sensor engineering, and drug receptor design

Research Workflow

Diffusion of protein backbone and sidechains around explicit ligand coordinates

Compute & Hardware

1x NVIDIA A100 or RTX 4090 GPU (>= 24GB VRAM)

Licensing & Academic Use

Open Source for academic research; commercial license required for for-profit use

Documented Evidence

View validation publication / source ↗

Use this citation format when referencing RFdiffusion All-Atom (RFdiffusionAA) in scientific publications and benchmark papers.

@software{rfdiffusion_all_atom_2026,
  title = {{RFdiffusion All-Atom (RFdiffusionAA)}},
  author = {{Institute for Protein Design (Baker Lab)}},
  year = {2026},
  url = {https://github.com/baker-laboratory/rf_diffusion_all_atom},
  note = {Indexed on aibioatlas - AI for Biology and Drug Discovery}
}