AI system for generating novel, high-affinity protein binders directly from target structures
AlphaProteo is Google DeepMind's generative protein design system that generates novel, high-affinity binders for diverse target proteins, including viral surface proteins (SARS-CoV-2 spike, BHRF1) and cancer-relevant receptors (VEGF-A, IL-17A, TrkA).
Generates high-affinity protein binders for diverse target proteins without initial starting fragmentsTrained on large macromolecular structure repositories and AlphaFold predictionsDemonstrates up to 300-fold higher binding affinities than prior computational design methodsExperimental success rates ranging from 9% to 88% across diverse target proteins in wet-lab biophysical assays
AlphaProteo is Google DeepMind's generative protein design system that generates novel, high-affinity binders for diverse target proteins, including viral surface proteins (SARS-CoV-2 spike, BHRF1) and cancer-relevant receptors (VEGF-A, IL-17A, TrkA).
信息已比对权威文献或官方白皮书;非实验性跑分。 权威出处 · 最后核对: 20/09/2026, 18:50:00 UTC
核心功能特性
Generates high-affinity protein binders for diverse target proteins without initial starting fragments
Trained on large macromolecular structure repositories and AlphaFold predictions
Demonstrates up to 300-fold higher binding affinities than prior computational design methods
Experimental success rates ranging from 9% to 88% across diverse target proteins in wet-lab biophysical assays
Interactive 3D Illustration
Biological Architecture (Stylized Ribbon)
Default view is a stylized demonstration ribbon. Enter any 4-letter RCSB PDB accession code above to stream real atomic coordinates.
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Illustrative Confidence Gradient:
>90 High / Low B 70-90 Confident 50-70 Low <50 Very low / High B
Academic Context & Research Evidence
Biological & Workflow Fit
Biological Application
De novo binder design, targeted cancer therapeutics, viral inhibitors, and biosensors
Research Workflow
Specify target protein structure and epitope binding site -> generate de novo binder sequences and 3D backbones
Compute & Hardware
GPU cluster for generative diffusion sampling and candidate filtering
Use this citation format when referencing AlphaProteo in scientific publications and benchmark papers.
@software{alphaproteo_2026,
title = {{AlphaProteo}},
author = {{Google DeepMind}},
year = {2026},
url = {https://deepmind.google/discover/blog/alphaproteo-generates-novel-proteins-for-biology-and-health-research/},
note = {Indexed on aibioatlas - AI for Biology and Drug Discovery}
}
Peer-Reviewed Literature & Preprints
Live scientific citations queried from Europe PMC and PubMed for AlphaProteo.
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技术参数与产品规格
Missing values mean the catalog has no recorded information. They do not mean a feature is absent.
Entry typeAI Model
Access modeResearch Preview
AI roleDe Novo Binder Design
Input dataNot recorded
Output dataNot recorded
Licence conditionsResearch Publication / DeepMind Research
Commercial eligibilityResearch publication & early academic collaboration
Compute requirementsGPU cluster for generative diffusion sampling and candidate filtering
ValidationNot recorded
TypeGenerative protein binder design model
Intended useNot recorded
CompatibilityNot recorded
ManufacturerGoogle DeepMind
Biological applicationDe novo binder design, targeted cancer therapeutics, viral inhibitors, and biosensors
Research workflowSpecify target protein structure and epitope binding site -> generate de novo binder sequences and 3D backbones
Evidence levelDeepMind Research Whitepaper & arXiv preprint (2024)