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将生物大模型、对接计算引擎与组学管线并排横向对比。按获取方式、硬件开销及细分领域灵活筛选，在一分钟内得出客观可辩护的技术选型方案。
| 技术参数指标 | ＋ 添加工具 | |||||
|---|---|---|---|---|---|---|
| Category | Genomics & Sequence Modeling | Genomics & Bioinformatics | Genomics & Bioinformatics | Genomics & Bioinformatics | Genomics & Bioinformatics | — |
| Subcategory | Bi-directional Mamba Genomic Models | Regulatory Genomics | Conventional or Statistical Baselines | Research AI Methods | Research AI Methods | — |
| Company | Stanford University & Princeton University | Google DeepMind | Research / method authors | Research / method authors | Research / method authors | — |
| Access mode | Open Source | Research code or publication | Confirm distribution and exact release | Confirm distribution and exact release | Confirm distribution and exact release | — |
| Licence conditions | Apache 2.0 | Check code and model weights separately | NOT_INDEPENDENTLY_AUDITED | NOT_INDEPENDENTLY_AUDITED | NOT_INDEPENDENTLY_AUDITED | — |
| Compute requirements | 1x GPU (>= 16GB VRAM) | Check selected checkpoint and runtime; no GPU catalog recommendation | Version and data dependent | Version and data dependent | Version and data dependent | — |
| Biological application | Long-range gene regulation, promoter-enhancer mapping, and variant impact scoring | 未明确记录 | 未明确记录 | 未明确记录 | 未明确记录 | — |
| Research workflow | Genomic DNA sequence -> predict regulatory activity with RC equivariance | 未明确记录 | 未明确记录 | 未明确记录 | 未明确记录 | — |
| Evidence level | Peer-reviewed research (ICML 2024) | Peer-reviewed primary method | PEER_REVIEWED_METHOD_OR_CONFERENCE | PEER_REVIEWED_METHOD_OR_CONFERENCE | PEER_REVIEWED_METHOD_OR_CONFERENCE | — |
| Commercial eligibility | Open source release | Unknown, requires audit | NOT_INDEPENDENTLY_AUDITED | NOT_INDEPENDENTLY_AUDITED | NOT_INDEPENDENTLY_AUDITED | — |
| Price | Free Open Source | Check selected model licence | Verify access and licence | Verify access and licence | Verify access and licence | — |
| Availability ⓘ | Available on GitHub and Hugging Face | Public research method/code | Method paper or official documentation | Method paper or official documentation | Method paper or official documentation | — |
| Features | Bi-directional state space (Mamba) architecture overcoming causal autoregressive limitations, Guaranteed reverse-complement (RC) equivariance essential for double-stranded DNA modeling, Sub-quadratic scaling allowing 131k base pair context on single standard GPUs, Superior performance on variant effect and chromatin accessibility benchmarks | Predicts genomic regulatory tracks and predicted functional effects of noncoding DNA variants., Genomic regulatory track, sequence-variant contrast | bcftools scientific method, Reference genome with aligned short-read input and correct ploidy assumptions, VCF/BCF variant calls and variants QC operations | CADD scientific method, Human genomic variant coordinates mapped to correct reference assembly, Combined annotation-dependent depletion scores | EVE scientific method, Protein family homolog alignment and compatible human missense variants, Evolutionary deep generative variant effect estimate | — |
| Entry type | AI Model | Research AI model / method | Classical/statistical scientific method | Source-scoped research method | Source-scoped research method | — |
| AI role | Equivariant State Space Modeling | Published biomedical AI method | NON_AI_STATISTICAL | ENSEMBLE_ML | DEEP_LEARNING | — |
| Input data | 未明确记录 | DNA sequence interval; alleles and tissue/assay ontology | Reference genome with aligned short-read input and correct ploidy assumptions | Human genomic variant coordinates mapped to correct reference assembly | Protein family homolog alignment and compatible human missense variants | — |
| Output data | 未明确记录 | Genomic regulatory track; sequence-variant contrast | VCF/BCF variant calls and variants QC operations | Combined annotation-dependent depletion scores | Evolutionary deep generative variant effect estimate | — |
| Validation | 未明确记录 | Requires independent dataset-specific evaluation | Published method scope; no independent BioAtlas execution or benchmark | Published method scope; no independent BioAtlas execution or benchmark | Published method scope; no independent BioAtlas execution or benchmark | — |
| Type | Bi-directional Mamba genomic model | 未明确记录 | 未明确记录 | 未明确记录 | 未明确记录 | — |
| Intended use | 未明确记录 | 未明确记录 | 未明确记录 | 未明确记录 | 未明确记录 | — |
| Compatibility | 未明确记录 | 未明确记录 | 未明确记录 | 未明确记录 | 未明确记录 | — |
| Manufacturer | Stanford University & Princeton University | 未明确记录 | 未明确记录 | 未明确记录 | 未明确记录 | — |
| Integration evidence | https://github.com/kuleshov-group/caduceus | 未明确记录 | 未明确记录 | 未明确记录 | 未明确记录 | — |
| Laboratory handoff | Informs non-coding variant prioritization for CRISPR functional genomics | 未明确记录 | 未明确记录 | 未明确记录 | 未明确记录 | — |