Issue #42September 17, 2026 · 6 min read
The Rise of All-Atom Diffusion & 98B Parameter Protein Foundation Models
A deep dive into EvolutionaryScale’s ESM-3 architecture, Baker Lab’s RFdiffusion All-Atom benchmark on small-molecule sensors, and the transition from sequence-only to multimodal physical modeling.
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Issue #41September 10, 2026 · 5 min read
Cryo-EM Meets Deep Learning: Resolving 1.2Å Conformational Dynamics
How RELION-5 and cryoSPARC 3DVA algorithms are decoding transient macromolecular intermediate states, enabling precision allosteric drug design.
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Issue #40September 3, 2026 · 8 min read
AI-Designed Clinical Candidates: The 2026 FDA Investigational New Drug Pipeline
Tracking 24 generative AI-designed small molecules and antibodies currently progressing through Phase I/II clinical trials across oncology and immunology.
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